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Product Name :
Pyrene-PEG-Biotin, MW 10k

Classification :
PEG Products / Pyrene-PEG-Biotin, MW 10k

Description :
Pyrene-PEG-Biotin is one of the many PEGylated pyrene derivatives for surface functionalization of carbon nanotubes and graphene. The strong (close to irreversible) pi-pi stacking between pyrene and the aromatic rings on single wall and multi-walled carbon nanotubes. Pyrene conjugation to PEG is through a very stable amide bond. It is a very simple process to prepare pyrene coated carbon nanoparticles (such as CNT). It requires just well dispersing CNTs with the PEG-pyrene reagents in either organic solvents or aqueous solutions. The same PEGylated pyrene reagent also works for graphene or any carbon nanoparticle surfaces with curvatures that fit well with the pyrene structure.Biotin offers the option to bind to streptavidin (SAV) or avidin. Custom synthesis of functional Pyrene-PEG derivatives is also available including: Pyrene-PEG-Pyrene, Amine-PEG-Pyrene, Acrylate-PEG-Pyrene, FITC-PEG-Pyrene, Rhodamine-PEG-Pyrene, Maleimide-PEG-Pyrene etc. MW options include 2k, 3.4k, 5k and 10k.

Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.Density: PEG density is approximately 1.125 g/mLPhysical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.

1) Effect of hydrophobic interaction in the poly(methacrylic acid)/pyrene end-labeled poly(ethylene glycol) complex, Macromolecules, 1987, 20 (8), pp 1839–1847, Text.2) Biotin-pyrene conjugates with poly(ethylene glycol) spacers are convenient fluorescent probes for avidin and streptavidin, Bioconjug Chem. 1997 Jul-Aug;8(4):560-6, Text.3) Non-covalent and reversible functionalization of carbon nanotubes, Beilstein J. Nanotechnol. 2014, 5, 1675–1690, Text.Click here to view an expanded list of hundreds of publications citing Creative PEGWorks products.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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