Histoacryl® glue injection has become a cornerstone in the endoscopic management of acute gastric variceal hemorrhage, offering rapid hemostasis with relatively low procedural risk. This study evaluates the clinical outcomes…
In this study, the immunomodulatory effects of inactivated Parapoxvirus ovis (iPPVO) were evaluated in mice following intraperitoneal inoculation. The cytokine expression profile was analyzed using real-time PCR (qPCR), ELISA for…
Recent advances in chromosomal spatial organization have been driven by chromosome conformation capture (3C) and its derivatives, which enable the detection of spatial proximity between genomic regions within the nucleus.…
Collagen is the most abundant protein in the human body, with 29 distinct types identified. These proteins serve as the primary structural components of connective tissues such as bone, tendon,…
Species of Candida, particularly *C. albicans* and increasingly *C. glabrata*, are major causes of life-threatening bloodstream infections (BSIs), especially in immunocompromised patients. Despite the urgent need for new antifungal agents,…
Knee osteoarthritis (KOA) is a progressive degenerative joint disease predominantly affecting older adults, characterized by cartilage degradation, subchondral bone remodeling, and chronic joint inflammation. Despite its high prevalence—reaching up to…
Heterocyst-forming cyanobacteria represent a remarkable example of bacterial multicellularity, where two metabolically distinct cell types—vegetative cells and heterocysts—work in tandem to sustain growth under nitrogen-limiting conditions. Vegetative cells perform oxygenic…
This phase 1 clinical trial evaluated the safety, pharmacokinetics (PK), and preliminary antitumor activity of MK-2206, an oral allosteric AKT inhibitor, in combination with standard chemotherapy agents or targeted therapy…
Hydrogen sulfide (H₂S), traditionally recognized as a toxic gas, is endogenously produced from L-cysteine in mammalian tissues. Its presence at relatively high concentrations in the brain suggests a physiological role…
**Background** Platelet aggregation plays a critical role in the formation of thrombi and the progression of various cardiovascular diseases. The P2Y12 receptor, a G protein-coupled receptor for adenosine 5′-diphosphate (ADP),…