Balanced group (mean difference =7 mOsmol/L (1 to 14); P = 0.024) (Figure 4A). The

Balanced group (mean difference =7 mOsmol/L (1 to 14); P = 0.024) (Figure 4A). The natraemia levels were greater inside the saline group than inside the balanced group (mean difference = 2 mmol/L (0 to 4); P = 0.036) (Figure 4B). ICP was not altered in the study group (mean difference = four mmHg (-1 to eight); P = 0.088) (Figure 4C). In the subgroup of TBI sufferers, blood osmolarity, natraemia and ICP weren’t altered in the study group (see Added file, Figure S2). Amongst the entire population, seven CCR1 Formulation sufferers (35 ) in the saline group and eight sufferers (40 ) inside the balanced group developed ICH (P = 0.744) (Table four). In the subgroup of patients who developed ICH, ICP was not altered by study group (mean distinction = -4 mmHg (-11 to 2); P = 0.20). (Added file, Figure S3).Security assessmentSafety outcomes had been assessed for the ITT patient population (Table four). Decompressive craniectomy wasRoquilly et al. Critical Care 2013, 17:R77 http://ccforum/content/17/2/RPage 6 ofTable two Baseline characteristicsaCharacteristics Age (years), median (IQR) Male, N ( ) Diagnosis, N ( ) Traumatic brain injury Subarachnoid haemorrhage Gap Junction Protein drug Glasgow Coma Scale score on scene, median (IQR) Surgical procedures, N ( ) Haematoma/contusion evacuation Extraventricular drainage Transfusion, median (IQR) Red blood cells, units Fresh frozen plasma, units Norepinephrine infusion on admission, N ( ) Fluid infusion before inclusion, median (IQR) Crystalloids (NaCl 0.9 ), ml Colloids, ml Time from brain injury to inclusion (hours) median (IQR) Biological status upon inclusion Hyperchloraemic acidosis, N ( ) Osmolarity (mOsm/L), median (IQR) Natraemia (mmol/L), median (IQR) Chloraemia (mmol/L), median (IQR) Kalemia (mmol/L), median (IQR) Ionized calcaemia (mmol/L), median (IQR) Magnesemia (mmol/L), median (IQR) Phosphoremia (mmol/L), median (IQR) Lactataemia (mmol/L), median (IQR) Azotaemia (mol/L), median (IQR) Albuminaemia (g/L), median (IQR) pH, median (IQR) SID (mmol/L), median (IQR)aIntention-to-treat population Saline (N = 21) 51 (25 – 68) 15 (71) 19 (90) two (10) 8 (7 – 9) 9 (43) two (ten) 4 (19) three (14) eight (38) 1000 (500 -1000) 0 (0 – 500) five (three – 7) 4 (19) 303 (295 – 319) 140 (138-142) 106 (104 – 110) 3.six (3.four – 3.9) 1.10 (1.07 – 1.14) 0.86 (0.72 – 0.95) 0.86 (0.67 – 1.07) 1.4 (1.1 – two.1) 66 (56-73) 36 (32 – 41) 7.38 (7.33 – 7.44) 39 (35 – 42) Balanced (N = 20) 49 (26 – 75) 17 (85) 18 (90) 2 (10) 7 (6 – 9) 4 (20) two (10) three (15) 0 7 (35) 1000 (500 – 1500) 0 (0 – 500) 5 (4 – 12) two (10) 302 (296 – 319) 139 (137-141) 106 (101 – 107) 3.7 (three.5 – 4.1) 1.11 (1.07 – 1.18) 0.81 (0.75 – 0.88) 0.85 (0.74 – 1.14) 1.7 (1.1 – two.7) 67 (58-71) 37 (34 – 39) 7.39 (7.32 – 7.45) 39 (39 – 41)TBI individuals Saline (N = 18) 47 (28-57) 13 (72) / 7 (6-8) 8 (44) 0 four (22) 3 (17) 7 (39) 500 (500 -1000) 0 (0 – 500) 4 (3-6) four (22) 306 (299-328) 140 (138-141) 106 (104-111) three.7 (three.4-3.9) 1.ten (1.08-1.12) 0.82 (0.76-0.92) 0.88 (0.70-1.ten) 1.5 (1.2-2.two) 65 (56-72) 34 (32-41) 7.36 (7.31-7.41) 40 (37-41) Balanced (N = 18) 49 (27-77) 16 (89) / 7 (6-8) 4 (22) 0 three (17) 0 7 (39) 1000 (500 -1500) 0 (0 – 500) 5 (4-6) two (11) 306 (300-319) 139 (137-141) 106 (100-107) 3.7 (three.5-4.1) 1.11 (1.06-1.18) 0.83 (0.73-0.92) 0.82 (0.73-1.13) 2.0 (1.1-2.7) 67 (60-71) 36 (34-39) 7.39 (7.31-7.45) 39 (37-41)IQR: interquartile variety; TBI: traumatic brain injury; Robust Ion Distinction (SID) = (Na + K + Ca + Mg) – (Cl + lactate).Table three Fluid administration inside the first 48 hoursMedian (IQR) Saline group (N = 20) Na administration (mmol) Cl a.