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Ments making use of tissue Doppler, considering that it was not routinely applied in 2005, in the starting in the study.manuscript. MH was inestimable in sample collection and clinical information collection. VD, EN, AB and DA are knowledgeable cardiologists who effected echocardiographic measurements, interpretation on the information and manuscript preparation. BM was accountable for statistical evaluation. HB participated in biochemical analysis of study samples. TZ, AL and VT provided specialist opinion, took critical aspect in information interpretation and manuscript preparation. All authors study and authorized the final manuscript. Acknowledgements This study was supported by research projects: RVO-VFN64165/2012 Ministry of Wellness along with the study project of Charles University P25/LF1/2. The authors are thankful to Mgr. Svarcov Mrs. Hudcovand Miskovskfor technical assistance. Author facts 1 Department of Nephrology, Initial Faculty of Medicine, Charles University, Prague, Czech Republic. 2Institute of Health-related Biochemistry and Laboratory Medicine, Initial Faculty of Medicine, Charles University and Basic University Hospital, Prague, Czech Republic. 32nd Department of Medicine Division of Cardiovascular Medicine Initially Faculty of Medicine, Charles University and Basic University Hospital, Prague, Czech Republic. 4Clinical Biochemistry, Haematology and Immunology, Na Homolce Hospital, Prague, Czech Republic. Received: 31 October 2012 Accepted: 26 June 2013 Published: 11 July 2013 References 1. Luke RG: Chronic renal failure: a vasculopathic state. N Engl J Med 1998, 339(12):84143. two. Pateinakis P, Papagianni A: Cardiorenal syndrome sort 4-cardiovascular illness in Mite Inhibitor review sufferers with chronic kidney disease: epidemiology, pathogenesis, and management. Int J Nephrol. 2011, 2011:938651. three. Kalantar-Zadeh K, Shah A, Duong U, Hechter RC, Dukkipati R, Kovesdy CP: Kidney bone disease and mortality in CKD: revisiting the role of vitamin D, calcimimetics, alkaline phosphatase, and minerals. Kidney Int Suppl 2010, 117:S10 21. 4. Covic A, Voroneanu L, Goldsmith D: The effects of vitamin D therapy on left ventricular structure and function – are these the underlying explanations for improved CKD patient survival Nephron Clin Pract 2010, 116(three):18795. five. Ogunyankin KO: Assessment of left ventricular diastolic function: the power, possibilities, and pitfalls of echocardiographic imaging methods. Can J Cardiol 2011, 27(3):31118. six. Nakamura T, Funayama H, Kubo N, Yasu T, Kawakami M, Momomura S, Ishikawa SE: Elevation of plasma placental growth factor within the sufferers with ischemic cardiomyopathy. Int J Cardiol 2009, 131(2):18691. 7. Torry RJ, Tomanek RJ, Zheng W, Miller SJ, Labarrere CA, Torry DS: Hypoxia increases placental growth element PDE4 Inhibitor medchemexpress expression in human myocardium and cultured neonatal rat cardiomyocytes. J Heart Lung Transplant 2009, 28(2):18390. 8. Pan P, Fu H, Zhang L, Huang H, Luo F, Wu W, Guo Y, Liu X: Angiotensin II upregulates the expression of placental development issue in human vascular endothelial cells and smooth muscle cells. BMC Cell Biol 2010, 11:36. 9. FialovL, KalousovM, SoukupovJ, SulkovS, Merta M, Jel kovE, HorejsM, Sr ek P, Malbohan I, Mikul ovL, Tesar V, Zima T: Connection of pregnancy- associated plasma protein-a to renal function and dialysis modalities. Kidney Blood Press Res 2004, 27(two):885. ten. Kim JK, Park S, Lee MJ, Song YR, Han SH, Kim SG, Kang SW, Choi KH, Kim HJ, Yoo TH: Plasma levels of soluble receptor for sophisticated glycation end solutions (sRAGE) and proinflammatory.

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