Hydrogen sulfide (H₂S), traditionally recognized as a toxic gas, is endogenously produced from L-cysteine in mammalian tissues. Its presence at relatively high concentrations in the brain suggests a physiological role…
**Background** Platelet aggregation plays a critical role in the formation of thrombi and the progression of various cardiovascular diseases. The P2Y12 receptor, a G protein-coupled receptor for adenosine 5′-diphosphate (ADP),…
Asthma remains a significant global health concern, with rising prevalence rates observed across diverse populations. Accurate diagnosis is essential for effective management, yet the absence of a universally accepted gold…
The regulation of gene expression in the human brain involves complex three-dimensional (3D) chromosomal architectures, particularly those involving long-range interactions between promoter and enhancer elements. This study focuses on chromosome…
Pancreatic cancer remains one of the most lethal malignancies, with a five-year survival rate below 5%. Early diagnosis is exceptionally rare, and surgical intervention is only effective when the disease…
**Background** Surfactants play a critical role in various biochemical and industrial processes, particularly in the solubilization of hydrophobic substances. In many research applications, the ability to sequester non-polar molecules into…
Gene coexpression domains represent functional units within genomes where multiple genes exhibit coordinated expression patterns. While such domains have been documented across various eukaryotic species, evidence for their presence in…
**Background** Glioma is a highly aggressive type of primary brain tumor characterized by rapid infiltration into surrounding brain tissue and a high rate of recurrence. Among the various subtypes, glioblastoma…
Breast cancer is a genetically heterogeneous disease driven by somatic mutations that confer clonal advantages to cancer cells. To elucidate the spectrum of driver mutations and mutational processes, we analyzed…
**Background** Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted by the intestinal L-cells in response to nutrient ingestion. It plays a critical role in glucose homeostasis by stimulating glucose-dependent insulin…