Name :
CD40 (Human) Recombinant Protein
Biological Activity :
Human CD40 (NP_001241.1, 21 a.a. – 193 a.a.) partial recombinant protein with a Fc, 6×His tag at the C-terminus expressed in HEK293 cells.Bioactive Protein,Bioactive Proteins,Bioactive,Active,Functional Protein,Functional Proteins,Recombinant Human Protein,Recombinant Human Proteins,Human Recombinant Protein,Human Recombinant Proteins,HuPro
Tag :
Result of activity analysis
Protein Accession No. :
P25942-1
Protein Accession No.URL :
https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=958
Amino Acid Sequence :
Molecular Weight :
Storage and Stability :
Store at -80°C on dry atmosphere, lyophilized antibodies are stable at least 2 years.After reconstitution with deionized water, store at -20°C or lower.Aliquot to avoid repeated freezing and thawing.
Host :
Human
Interspecies Antigen Sequence :
Preparation Method :
Mammalian cell (HEK293) expression system
Purification :
Ni-sepharose purification
Quality Control Testing :
SDS-PAGE Stained with Coomassie Blue
Storage Buffer :
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Applications :
SDS-PAGE，
Gene Name :
CD40
Gene Alias :
Bp50, CDW40, MGC9013, TNFRSF5, p50
Gene Description :
CD40 molecule, TNF receptor superfamily member 5
Gene Summary :
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations :
B cell surface antigen CD40|B cell-associated molecule|CD40 antigen|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|OTTHUMP00000031699|OTTHUMP00000031700|nerve growth factor receptor-related B-lymphocyte activation mol
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